The clinically studied strain Lactiplantibacillus plantarum ECGC13110402 engages bile acid metabolism in the gut — a pathway research links to cholesterol regulation. Plus a polyphenol extract from lemon verbena and hibiscus and vitamins; vitamin B1 contributes to normal heart function and energy production.
Cholesterol and metabolic syndrome can develop silently for years - and most probiotics do not address them at all.
Cardiovascular diseases are among the most common causes of death worldwide. According to WHO, they are responsible for more than 17 million deaths every year. Their development is linked to multiple factors including metabolic processes, lifestyle and the body's overall balance.
Metabolic syndrome is the clinical term for a state in which several risk factors occur together in one person - elevated cholesterol and triglycerides, high blood pressure, higher blood glucose and abdominal obesity. If at least three are present, the risk of heart attack, stroke or type 2 diabetes rises substantially.
CARDIObiom+® uses the clinically studied strain L. plantarum ECGC13110402 with a unique mechanism of action – the breakdown of bile acids in the gut. Because bile acids are produced from cholesterol, this mechanism represents an innovative approach to cholesterol metabolism. The formula is completed by polyphenols from lemon verbena and hibiscus.
Cholesterol is not produced only in the liver. A major part of your metabolism is managed by bacteria in the gut - and most probiotics ignore this.
Lactiplantibacillus plantarum ECGC13110402 has its own code, its own clinical history and a clearly described mechanism supporting bile acid metabolism. No vague "mix of good bacteria".
30 coloured capsules release content in the stomach, and 30 white enteric capsules deliver active substances directly to the intestines. One formulation, two sites of action.
Polyphenol extract from lemon verbena and hibiscus - more than 20 years of research, 8 clinical studies and 10 scientific publications. Synergy with the probiotic, not an isolated "supplement".
Thiamine (B1) contributes to normal heart function and energy-yielding metabolism. Vitamin D3 (cholecalciferol) contributes to normal immune function and calcium absorption. No "miracle" promises - only authorised claims.
Cardiometabolic health is not one single function. CARDIObiom+® was formulated to support four interconnected areas at once.
The clinically studied strain L. plantarum ECGC13110402 is among the few bacterial strains with a precisely described mechanism of action in the area of cholesterol metabolism.
Polyphenols from lemon verbena and hibiscus have been studied in connection with mechanisms affecting insulin response and glucose metabolism.
Vitamin B1 contributes to normal energy-yielding metabolism, which converts nutrients into energy, and also contributes to the normal function of the heart.
The gut microbiome is one of the most researched areas of modern science for its links to metabolism and cardiometabolic health.
30 coloured + 30 white capsules · 4 × 10⁹ CFU per daily dose
Most probiotics break down in the stomach. CARDIObiom+® uses a dual-capsule system - one capsule releases polyphenols where they support bile and metabolism, while the other delivers viable bacteria and vitamins to the intestines.
No "universal" probiotic. Each ingredient has a precise purpose and evidence base.
*NRV = nutrient reference values - recommended daily amounts of vitamins and minerals for adults set by the European Union (EU Regulation 1169/2011).
The figures below are results from independent randomized clinical studies on the probiotic strain L. plantarum ECGC13110402 and the polyphenol extract from lemon verbena and hibiscus - the same active ingredients found in CARDIObiom+®.
60 capsules · 30-day dose · transparent composition
| L. plantarum ECGC13110402 | 4 × 10⁹ CFU |
| Release target | Intestine |
| Mechanism | Bile acid metabolism |
| Clinical studies | RCT, 6-12 weeks |
| Dosing | 1 capsule in the morning, on an empty stomach |
| Form | 30 enteric capsules |
| Lemon verbena + hibiscus extract | 500 mg |
| Vitamin D3 (cholecalciferol, 100% NRV) | 15 μg |
| Vitamin B1 (thiamine, 80% NRV) | 0.88 mg |
| Dosing | 1 capsule in the morning, on an empty stomach |
| Form | 30 gastric-active capsules |
NRV = nutrient reference values - recommended daily amounts of vitamins and minerals for adults set by the European Union (EU Regulation 1169/2011).
We reviewed the three most popular categories of heart and cholesterol supplements on the Slovak market - red yeast rice, omega-3 and plant sterols - and compared them with CARDIObiom+®.
| CARDIObiom+® | Red yeast rice (monacolin K) | Omega-3 supplements (EPA/DHA) | Plant sterols (phytosterols) | |
|---|---|---|---|---|
| Clinically studied targeted strain for the cardiometabolic microbiome | ✓ L. plantarum ECGC13110402 | ✕ | ✕ | ✕ |
| Acts through the gut-heart axis (microbiome) | ✓ | ✕ | ✕ | ✕ |
| Standardized polyphenol extract | ✓ 500 mg verbena + hibiscus | ✕ | ✕ | ✕ |
| EFSA-authorised health claim for heart function | ✓ Vitamin B1 (thiamine) | ✕ | ✓ EPA + DHA | ✕ |
| EFSA-authorised claim for immunity (vitamin D3, cholecalciferol) | ✓ Vitamin D3 (cholecalciferol) | ✕ | ✕ | ✕ |
| No monacolin K (no statin-like effect or interactions) | ✓ | ✕ contains | ✓ | ✓ |
| No restrictions for risk groups1 | ✓ | ✕ EU limit since 2022 | ✓ | ✓ |
| Main mechanism of action | Multi-mechanism: cholesterol + blood pressure + metabolism + microbiome | HMG-CoA inhibition (like statins) | Heart function, triglycerides | Blocks cholesterol absorption |
1 From 22 June 2022, the EU limited monacolin K content in supplements to < 3 mg/day and does not recommend them for pregnant women, breastfeeding women, people over 70, children, adolescents and patients using lipid-lowering medicines (statins). Source: EU Regulation 2022/860, EFSA.
40 years of microbiome research. Three people who bridged science and product - functional microbiome solutions for longevity and health.
Cholesterol is not only a liver issue. A large part of its metabolism is managed by gut bacteria - which is why a probiotic is a logical tool.
Just as physicians know which molecule influences which process, we need the same understanding for probiotics. CARDIObiom+® is proof of that.
A quality probiotic must be built on scientific evidence and real clinical data - not on marketing promises.
Martin Haranta, co-founder of iProbio, explains in two minutes what metabolic syndrome is, how the gut microbiome relates to it, and who we designed CARDIObiom+® for.
1:59 109 articles in Slovak media in 2025.
"We launched production two years ago and currently have thousands of clients monthly and very positive feedback."
"Probiotics are not a matter of faith, but of scientific and clinical evidence."
"If you find a product that only says Lactobacilus acidophilus without a number, that is a sign of poor quality."
"Probiotics are more like guided missiles."
"The quality and health of our gut significantly affects our whole life, not just mental health but physical health too."
"The microbiome is connected to virtually every system in the body."
A selection of media coverage of the brand and its founders. Logos belong to the respective media outlets.
It is not an ordinary "heart supplement". CARDIObiom+® combines clinically studied ingredients selected based on modern scientific insights into cardiometabolic health.
For people who want to pay greater attention to areas related to metabolism – such as cholesterol, energy balance and everyday habits.
The body's metabolic processes and the gut microbiome are the subject of intensive scientific research for their mutual connections and link to cardiometabolic health.
For people who spend a lot of time sitting and are looking for a science-based approach to caring for their health alongside a demanding work routine.
1 coloured + 1 white capsule in the morning, on an empty stomach, with water
Children under 12, pregnant and breastfeeding women, people with hypersensitivity to ingredients
We recommend at least 3 months for more lasting change in the gut microbiome
Room temperature (up to 25 °C), in a dry and dark place
No. CARDIObiom+® is a food supplement, not a medicine. If your doctor prescribed medication, do not stop taking it without consultation. CARDIObiom+® can serve as complementary support for cardiometabolic health within an overall healthy lifestyle.
The pack contains 30 coloured capsules (active in the stomach) and 30 white capsules (active in the gut). Each ingredient is released where it is intended to act - polyphenol extract in the stomach, L. plantarum ECGC13110402 in the small intestine. They are taken together, at the same time, in the morning.
Clinical studies observed that polyphenol effects on satiety can appear within weeks, while microbiome changes require a longer period. In clinical studies, the average observation period was 6–12 weeks. We recommend at least 3 months for a realistic evaluation.
No. The figures in the "What research says" section come from clinical studies on the strain and extract themselves - findings that inspired the formulation. Individual outcomes vary by health status, lifestyle and genetics. Under European regulation, only EFSA-authorised claims for vitamin B1 (thiamine) and vitamin D3 (cholecalciferol) apply as product effects of CARDIObiom+®.
Yes. With the prebiotics Mikrobióm+® and POWERbiom+®, the combination is recommended - they do not introduce new strains but nourish your microbiome, so they can be taken together, at the same time, in the morning. With other iProbio probiotics (HIT na Trávenie+®, VITALbiom+®), we recommend a time gap - one probiotic in the morning, the other in the evening, so individual strains do not compete in the gut.
No. CARDIObiom+® is not intended for pregnant or breastfeeding women and for children under 12.
Generic supplements combine vitamins and several herbs without a specific mechanism. CARDIObiom+® contains the specific strain L. plantarum ECGC13110402, a standardized polyphenol extract with 20+ years of research and 8 clinical studies, and EFSA-authorised amounts of vitamin B1 (thiamine) and vitamin D3 (cholecalciferol). Each ingredient has a clear purpose and evidence base.
Clinically studied strain. Standardized polyphenol extract. EFSA-authorised heart claims. Launch May 2026.
