We only deal with immunity when we need it
One cold passes and a few weeks later we are dealing with another. Vitamin C, tea and other “seasonal” fixes come out only with the first symptoms – and the next round we start over.
Targeted probiotic
Immunity does not start in the nose. It starts in the gut.
The immune system is complex – which is why iMunobiom+® does not put everything on a single ingredient. It combines a specific bacterial strain, Lacticaseibacillus rhamnosus CRL 1505, yeast beta-glucans and vitamin D3 – three distinct ingredients, each with a role in the formulation. Strain CRL 1505 and yeast beta-glucans bring two distinct, research-studied pathways of interaction with the immune system, while vitamin D contributes to its normal function*. One considered formulation for everyday use by children and adults.
CRL 1505 · one of the most extensively studied bacterial strains
Yeast beta-glucan · a form with clinical research
Vitamin D3 from lichen · vegan source
* Vitamin D contributes to the normal function of the immune system. EU-authorised health claim for vitamin D.
They wrote about us
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The same round of colds every winter?
Immunity is not just about vitamin C in December. The gut and the immune system are closely linked – and looking after them makes sense all year round.
We expect a supplement to be a quick rescue
A food supplement is often seen as a quick fix. The immune system is complex and closely linked to the gut microbiome – so it is worth looking at its support in a broader context.
Not more. Targeted.
iMunobiom+® combines three ingredients with different roles in the formulation. Regularity matters too – it is designed for longer-term use, not just a few days in season.
Explained by Martin Haranta · CEO and co-founder of iProbio“Probiotics do something for immunity.” That claim says nothing.
The immune system is the second most complex system in the body after the nervous system, so the phrase “supports immunity” on its own says nothing. In a few minutes Martin Haranta explains what the strain in iMunobiom+® actually does and why its mechanism is also known.
- One of the best-documented bacterial strainsLacticaseibacillus rhamnosus CRL 1505 has more than 35 preclinical and clinical studies behind it. Research also looks at how the strain acts – including a strain-specific peptidoglycan in the cell wall and its role in the observed immune response.
- The gut–lung axisThe strain is taken by mouth and acts in the gut, yet the literature also describes a signal reaching the airways. That is known as the gut-lung axis.
- Beta-glucans are also food for bacteria450 mg of beta-glucans from Saccharomyces cerevisiae. Beta-glucan is a polysaccharide, so besides its own role it also serves in the gut as food for beneficial bacteria.
- Vitamin D3 from lichenLichen is one of the few plant sources of vitamin D3 in its natural form, cholecalciferol – the same form the body makes in sunlight. It is obtained by gentle UV irradiation of lichen, 800 IU in the daily dose, suitable for vegans too. Vitamin D contributes to the normal function of the immune system.
“If the science on a specific probiotic strain is done properly, I know exactly how it stimulates immunity and what I can expect from it.”
Martin Haranta · CEO and co-founder of iProbioWhy iMunobiom+®
It is not enough to know which bacterium is in the capsule. The specific strain matters too. That is what determines its particular properties.
CRL 1505 – studied effects and mechanism of action
With strain CRL 1505, research does not only look at what was observed, but also at how the strain acts. Specific structures of its cell wall and their role in the observed immune response are studied too.
Vitamin D3 from lichen
A vegan source of vitamin D3 in a deliberately chosen daily dose. Its place in the formulation has a clear reason – vitamin D contributes to the normal function of the immune system.
Beta-glucans from Saccharomyces cerevisiae yeast
Not every beta-glucan is the same. The yeast (1,3)-(1,6)-β-D form has its own clinical research, including studies focused on the immune response and upper respiratory infections.
One formulation for children and adults
CRL 1505 withstands stomach acid and bile and does not produce histamine or other biogenic amines. The formulation is intended for everyday use by children and adults.
We look at immunity in context
Immunity is not one isolated process. It is linked to what happens in the gut, how the immune system responds and to processes on the respiratory mucosa. Research looks at these connections too.
01
Immune response
Strain CRL 1505 has been studied in relation to the immune system’s reaction to various viruses and bacteria, including those linked to the airways and the gut.
02
Respiratory tract
A substantial part of CRL 1505 research focuses on the upper airways, especially in periods when respiratory infections are more common.
03
Immunity and the gut
The gut and the immune system are closely linked. Both CRL 1505 and beta-glucans are studied for interactions with the gut environment – CRL 1505 in relation to the immune response, beta-glucans in relation to gut bacteria.
04
Immunity and vitamin D
Vitamin D has a clearly defined role in the immune system – it contributes to its normal function. That is why it is one of the three core ingredients of iMunobiom+®.
A specific strain. A specific role.
strain CRL 1505 beta-glucans vitamin D3
Two capsules daily · 1 × 10⁹ CFU in the daily dose
A specific strain. A specific role.
iMunobiom+® combines a bacterial strain, yeast beta-glucans and vegan vitamin D3 in one daily dose. Simple composition and simple use make it easy to fit the routine to individual needs.
Adults and children from 3 years
2 capsules in the morning, on an empty stomach, with a glass of water. Children aged 3 to 12: 1 capsule daily.
Time away from food
About 15 to 20 minutes before the first meal
Regularity
Every day, including weekends and holidays
Course length
At least 3 months
Storage
Room temperature (up to 25 °C), a dry, dark place
iMunobiom+® is not suitable for children under 3, pregnant or breastfeeding women, or anyone hypersensitive to any of the ingredients. If you have health issues or take medication, consult a doctor.
This refers to composition and how to take it. These are not claims about an effect in the human body.
One strain. Two supporting ingredients.
No “universal” immune blend. Each ingredient has a reason and a basis.
1
Lacticaseibacillus rhamnosus CRL 1505
One of the most studied bacterial strains – 35+ preclinical and clinical studies and 50+ scientific publications. Resistant to stomach acid and bile.
1 × 10⁹ CFU
Beta-glucans (Saccharomyces cerevisiae)
A precisely defined (1,3)-(1,6)-β-D-glucan from yeast, studied in clinical trials in relation to immune response and respiratory infections.
450 mg
Vitamin D3 (vegan from lichen)
A plant source of vitamin D3 in a thoughtfully chosen daily dose. Vitamin D contributes to the normal function of the immune system and the process of cell division.
800 IU
Daily dose: 1 × 10⁹ CFU strain CRL 1505 + 450 mg beta-glucans + 800 IU vitamin D3 (cholecalciferol)
What the research says
The ingredients in iMunobiom+® have been studied in clinical trials. We present their design, dosage and what was measured. Study results relate to the individual ingredients studied and the forms and doses used, not to the finished iMunobiom+® product.
Strain Lacticaseibacillus rhamnosus CRL 1505
Randomised, double-blind, placebo-controlled study
RCT · n = 298 · deti 2–5 rokov · 6 mesiacov Study design RCT, double-blind Source: Villena et al., 2012
A randomised, double-blind, placebo-controlled study in children. Strain CRL 1505 was given in yoghurt five times a week.
Number of participants n = 298 Source: Villena et al., 2012
Healthy children aged 2 to 5 attending day-care centres.
Daily dose in the study ≥ 1 × 10⁸ CFU Source: Villena et al., 2012
Sweetened yoghurt containing at least 1 × 10⁸ CFU/100 g; children received 100 g daily, five times a week (≥ 1 × 10⁸ CFU/day).
What was measured Incidence of intestinal infections, upper respiratory tract infections and tonsillitis, fever episodes, antibiotic use and mucosal IgA levels. Source: Villena et al., 2012
Villena et al., Int. J. Biotechnol. Wellness Ind. 2012; 1:189 to 198.
Strain Lacticaseibacillus rhamnosus CRL 1505
Randomised, double-blind, placebo-controlled study
RCT · n = 140 · 12 weeks Latest study · 2026
Study design RCT, double-blind Source: Taverniti et al., 2026
A randomised, double-blind, placebo-controlled study in adults; 12 weeks of supplementation and a 4-week follow-up.
Number of participants n = 140 Source: Taverniti et al., 2026
140 randomised adults (70 + 70); 122 included in the final analysis (60 + 62).
Daily dose in the study 1 × 10⁹ CFU Source: Taverniti et al., 2026
CFU = colony forming units, the number of viable microorganisms in the daily dose.
What was measured Incidence of upper respiratory tract infections (URTI), their number and duration, use of symptom medication and salivary IgA levels. Source: Taverniti et al., 2026
Taverniti et al., Microorganisms 2026; 14:1270.
(1,3)-(1,6)-β-glucan from Saccharomyces cerevisiae
Randomised, double-blind, placebo-controlled multicentre study
RCT · n = 162 · 16 weeks Study design RCT, multicentre Source: Auinger et al., 2013
A randomised, double-blind, placebo-controlled study at multiple sites in healthy adults.
Number of participants n = 162 Source: Auinger et al., 2013
162 healthy adults with recurrent infections (81 + 81).
Daily dose in the study 900 mg Source: Auinger et al., 2013
Daily amount of insoluble (1,3)-(1,6)-β-glucan used in the study.
What was measured Number of common cold episodes, infection symptom scores and sleep disturbance during colds. Source: Auinger et al., 2013
Auinger et al., Eur. J. Nutr. 2013; 52:1913 to 1918.
(1,3)-(1,6)-β-glucan from Saccharomyces cerevisiae
Randomised, double-blind, placebo-controlled study
RCT · n = 291 · 16 weeks Study design RCT, double-blind Source: Dharsono et al., 2019
A prospective, single-centre, randomised, double-blind, placebo-controlled study in healthy adults.
Number of participants n = 291 Source: Dharsono et al., 2019
291 randomised healthy adults with recurrent infections (146 placebo + 145 β-glucan).
Daily dose in the study 900 mg Source: Dharsono et al., 2019
900 mg insoluble (1,3)-(1,6)-β-glucan from yeast daily, in two capsules.
What was measured Global severity, incidence and duration of upper respiratory tract infections, blood pressure and mental well-being. Source: Dharsono et al., 2019
Dharsono et al., J. Am. Coll. Nutr. 2019; 38(1):40 to 50.
Read more about the research and selected studies in our scientific PDF
What is in the pack
60 capsules · transparent composition
Bacterial strain
| Lacticaseibacillus rhamnosus CRL 1505 | 1 × 10⁹ CFU |
| Resistance (acid/bile) | ✓ |
| Does not produce histamine | ✓ |
Supporting ingredients
| Beta-glucans (Saccharomyces cerevisiae) | 450 mg |
| Vitamin D3 (cholecalciferol) | 800 IU |
| D3 source | lichen (vegan) |
Dosage: Adults 2 capsules (children aged 3 to 12: 1 capsule) daily
Recommended course: At least 3 months
Recommended course: At least 3 months
Strain does not produce histamine Vegan vitamin D3 GMO-free No artificial colours Resistant to stomach acid
How we compare
We compared iMunobiom+® with what people usually reach for during flu season.
| iMunobiom+® | Vitamin C / “fizzy tablets” | Generic probiotics | |
|---|---|---|---|
| Specifically identified bacterial strain | ✓ CRL 1505 | ✕ | not always |
| Strain backed by its own research | ✓ 35+ studies | ✕ | not always |
| Beta-glucans in the formulation | ✓ | ✕ | usually not |
| Vitamin D3 in the formulation | ✓ 800 IU | ✕ | usually not |
| Non-histamine-producing strain | ✓ | ✕ | not always |
Who stands behind iProbio
40 years of experience in microbiome research. Three people united by the aim of turning scientific knowledge into considered, functional products.
MVDr. Alojz Bomba, DrSc.
Co-founder and scientific director
"
Most of the data we have is on a few specific strains. CRL 1505 is one of them - that is why we build immune support on it, not on a random blend.
40 years of intestinal microbiome research 295 citations in scientific papers 31 international research projects 25 years as organiser of the International Probiotic Conference
Martin Haranta, MSc.
Co-founder and CEO
"
A specific strain for a specific problem. That is the whole difference between a targeted probiotic and a random mix of “good bacteria”.
MSc., The Open University, UK 8 international research and innovation projects 3 scientific publications Founder of the ARCOBIOME centre (UPJŠ Košice)
Ing. Norbert Bomba
Co-founder & CBDO
"
A quality probiotic must be built on scientific evidence and real data from clinical practice - not on marketing promises.
20+ years in biotechnology Co-founder of PerBiotiX 25 years as organiser of the International Probiotic Conference Director of Cassovia Life Sciences
Where our science comes from
40+ years of research you can see in the composition
The scientific career of our co-founder MVDr. Alojz Bomba, DrSc. goes back to the 1980s. In 1990 he co-founded a gnotobiotic laboratory in Slovakia, the only facility of its kind, and in 2000 he founded an international scientific conference on probiotics and prebiotics.
- ✓Gnotobiotic laboratory since 1990: an environment where the effect of one strain can be separated from everything else.
- ✓The potentiated probiotics concept: selected strains combined with companion ingredients of natural origin.
- ✓The IPC conference since 2000, which Dr Bomba founded and chaired until 2015.
They wrote about us
From Forbes to the national science portal
109 articles in Slovak media in 2025.
"We launched production two years ago and currently have thousands of clients every month and very positive feedback."
"Probiotics are not a matter of faith, but of scientific and clinical evidence."
"If you find a product that lists only <em>Lactobacillus acidophilus</em> without a number, that is a sign of poor quality."
"Probiotics are more like guided missiles."
"The quality and health of our gut significantly affects our whole life, not just our mental state but also our physical health."
"The microbiome is connected, in essence, to every system in the body."
A selection of media coverage of the brand and its founders. Logos belong to the respective media.
Who iMunobiom+® is for
It is not just another “immunity” supplement. We designed its composition with the specific needs of children and adults in mind.
Families with children
Nursery, school and viruses circulating through the whole household. One formulation for children and adults that fits into the daily routine.
Frequent, repeated colds
One passes and a few weeks later the next one arrives. You are looking for a longer-term approach to immunity, not just something for the first symptoms.
When you watch the composition
Both CRL 1505 and yeast beta-glucans are clinically studied. The formulation is completed by vitamin D3 from lichen – a vegan source.
Frequently asked questions
How is it different from ordinary “vitamin C for immunity”?
iMunobiom+® is not built on a single ingredient or short-term seasonal use. It combines strain CRL 1505, clinically studied yeast beta-glucans and vitamin D3 in one formulation designed for regular, longer-term use.
Is it suitable for children?
Yes. iMunobiom+® is intended for children aged 3 to 12. The recommended dose is 1 capsule daily.
Why vegan vitamin D3?
Because origin matters too. We chose D3 from lichen instead of the commonly used lanolin from sheep’s wool – no animal source, and suitable for vegans.
Does CRL 1505 produce histamine?
No. Strain CRL 1505 does not produce histamine. It is also resistant to stomach acid and bile.
Can it be combined with other iProbio products?
Yes. You can combine iMunobiom+® with other iProbio products. It can be taken at the same time as Mikrobióm+®; with HIT na Trávenie+® we recommend a time gap – one product in the morning and the other in the evening.
What customers say
Real experiences and ratings from iProbio users.
Support immunity from where it begins
One of the most studied bacterial strains. Vitamin D3 and beta-glucans. 40 years of microbiome research.
1 month · 44,06€
3 months · 115,99€ · You save 42,27€
6 months · 223,89€ · You save 118,71€
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